Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
Description
The second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca^(2+)) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding to TPCs, NAADP
