Kinetics of trisulfide-to-disulfide conversion of therapeutic IgG1 monoclonal antibodies under physiological conditions: a case study of casirivimab and imdevimab
Description
The percentage of trisulfide variants is a product quality metric that is monitored during the manufacture of monoclonal antibody (mAb)-based therapeutics. Results from earlier preclinical studies revealed that trisulfide linkages in mAbs are rapidly
