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PubMed COVID-19 Clinical Care

14271 - 14280 of 57753 results found

Development of a non-invasive ventilator for emergency and beyond

Date
Wednesday, November 08, 2023 - 4:00 AM
Description
The SARS-CoV-2 pandemic led to the development and implementation of emergency ventilators owing to the shortage of ventilators globally. Using invasive ventilators for patient intubation has medical experts concerned about increasing mortality

Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Date
Wednesday, November 08, 2023 - 4:00 AM
Description
CONCLUSIONS: The emergence of E484A and E484Q prior to widespread population immunity may have been limited by fitness costs. In populations already exposed to the early immune escape epitope E484K, the Omicron founder background may have provided a