Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants
Description
Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies carry no or only a few mutations, leaving the question of how ongoing SHM