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PubMed COVID-19 Clinical Care

50051 - 50060 of 57753 results found

Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

Date
Saturday, April 15, 2023 - 4:00 AM
Description
The high morbidity and mortality associated with SARS-CoV-2 infection, the etiological agent of COVID-19, has had a major impact on global public health. Significant progress has been made in the development of an array of vaccines and biologics

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors

Date
Saturday, April 15, 2023 - 4:00 AM
Description
Virus entry into animal cells is initiated by attachment to target macromolecules located on host cells. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) trimeric spike glycoprotein targets host angiotensin converting enzyme 2 to gain