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PubMed COVID-19 Clinical Care

21851 - 21860 of 57753 results found

Regulation of human interferon signaling by transposon exonization

Date
Monday, September 25, 2023 - 4:00 AM
Description
Innate immune signaling is essential for clearing pathogens and damaged cells, and must be tightly regulated to avoid excessive inflammation or autoimmunity. Here, we found that the alternative splicing of exons derived from transposable elements is

Acute Cardiac Manifestations of SARS-CoV-2 Infection: Spotting the Clot

Date
Monday, September 25, 2023 - 4:00 AM
Description
A middle-aged gentleman presented with a one-week history of progressive dyspnoea on minimal exertion, persistent haemoptysis, and right calf swelling. His only past medical history of note was a recently positive SARS-CoV-2 nasopharyngeal swab

Examining Functional Linkages Between Conformational Dynamics, Protein Stability and Evolution of Cryptic Binding Pockets in the SARS-CoV-2 Omicron Spike Complexes with the ACE2 Host Receptor: Recombinant Omicron Variants Mediate Variability of Conserv...

Date
Monday, September 25, 2023 - 4:00 AM
Description
In the current study, we explore coarse-grained simulations and atomistic molecular dynamics together with binding energetics scanning and cryptic pocket detection in a comparative examination of conformational landscapes and systematic