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PubMed COVID-19 Clinical Care

16921 - 16930 of 57753 results found

Repurposing of H1-receptor antagonists (levo)cetirizine, (des)loratadine, and fexofenadine as a case study for systematic analysis of trials on clinicaltrials.gov using semi-automated processes with custom-coded software

Date
Monday, October 23, 2023 - 4:00 AM
Description
To gain a comprehensive overview of the landscape of clinical trials for the H(1)-receptor antagonists (H(1)R antagonists) cetirizine, levocetirizine, loratadine, desloratadine, and fexofenadine and their potential use cases in drug repurposing (the

Tetanus: an immunopreventable disease

Date
Monday, October 23, 2023 - 4:00 AM
Description
Tetanus is an infectious disease caused by a ubiquitous bacterium Clostridium tetani, that synthesizes and releasesa potent neurotoxin under anaerobic conditions, which is responsible for the clinical manifestations. As it is found in soil

Evolutionary stability of antigenically escaping viruses

Date
Monday, October 23, 2023 - 4:00 AM
Description
Antigenic variation is the main immune escape mechanism for RNA viruses like influenza or SARS-CoV-2. While high mutation rates promote antigenic escape, they also induce large mutational loads and reduced fitness. It remains unclear how this cost