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PubMed COVID-19 Clinical Care

10511 - 10520 of 57753 results found

Insights into the ISG15 transfer cascade by the UBE1L activating enzyme

Date
Saturday, December 02, 2023 - 4:00 AM
Description
The attachment of the ubiquitin-like protein ISG15 to substrates by specific E1-E2-E3 enzymes is a well-established signalling mechanism of the innate immune response. Here, we present a 3.45 Å cryo-EM structure of a chemically trapped UBE1L-UBE2L6