Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication
Description
Human Angiotensin-Converting Enzyme 2 (hACE2) is the major receptor enabling host cell invasion by SARS-CoV-2 via interaction with Spike. The murine ACE2 does not interact efficiently with SARS-CoV-2 Spike and therefore the laboratory mouse strains
