Drug-Drug Interactions and Dose Management of BTK inhibitors When Initiating Nirmatrelvir/Ritonavir (Paxlovid) Based on Physiologically-Based Pharmacokinetic Models
Description
CONCLUSIONS: The PBPK models predicted the in vivo pharmacokinetics and the DDIs of BTK inhibitors and ritonavir. The prospective simulations not only provided scientific evidence regarding rational dosing management strategies when initiating
