Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Description
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)^(1,2), conferring a predisposition to life-threatening COVID-19
